Does My Gene of Interest Affect Survival?
You can use Xena Kaplan Meier plot (KM plot) to test whether a genomic or phenotype variable significantly affects survival.
IDH1 is an enzyme that affects metabolism in tumors and is frequently mutated in Lower Grade Glioma.
Running a KM analysis, we can see there is a significant overall survival difference between patients with IDH1 mutation and those without.
To Reproduce the IDH example
Go to our Visualization tab
Select the TCGA Lower Grade Glioma cohort
Add the Somatic Mutation SNPs and small INDELs (Broad automated) dataset
Enter the gene 'IDH1'
Note that there is a '!' warning at the top of the plot indicating that some samples are in the plot twice (normal, recurrent tumor, metastasis, etc). To remove duplicate samples, please see our help page.
How to remove duplicate samples?
Have you ever noticed the warning icon in the top corner of a KM plot? Read here