What Is the Pattern between My Two Genes of Interest?
Telomere lengthening is one of the hallmarks of cancer. Decreased ATRX expression (by processes that destroy the gene including germline and somatic mutations) is associated with the lengthening of telomeres. Increased TERT expression is also associated with telomere lengthening, by increased telomerase activity.
We can see that increased TERT expression is associated with regular ATRX expression and that decreased ATRX expression is associated with regular TERT expression (note that both columns are mean normalized, making 'normal' appear either high or low). This suggests that these pathways are mutually exclusive in Lower Grade Glioma.
The third column shows mutations in ATRX with the transcript along the top, with alternating light and dark gray exons. Mutations are colored by their functional impact, with mutations predicted to not make a protein in red, mutations predicted to make a protein but perhaps with altered function in blue and synonymous mutations in green. We can see that the ATRX mutations predicted to not make a protein are associated with lowered ATRX expression.
bookmark view : ATRX and TERT expression in TCGA LGG
Learn to do This Yourself
Go to our Visualization tab at the top of the page.
Select the TCGA Lower Grade Glioma cohort
Enter the gene 'ATRX' and select 'gene expression' and 'mutation'. Click 'Done'.
Repeat for the gene TERT.
Hover over the column headers to see the controls to drag columns side to side. Rearrange columns to match the image above.